Welcome to the Sanhueza Research Group
Organic synthesis Medicinal chemistry Glycosciences
Department of Pharmaceutical Sciences
St. John's University
We are a research team interested in the design and synthesis of carbohydrates and glycomimetic compounds with applications in chemical biology and drug discovery. Our main focus is on glycans associated with neglected tropical diseases (NTD) such as Trypanosoma cruzi (Chagas disease), Schistosoma mansoni (Schistosomiasis), and Leishmania donovani (Leishmaniasis). Current projects in our group are directed to synthesize carbohydrate fragments associated with the cell surface of these parasites to develop vaccine candidates and serological detection tools. Other research lines in our group include the design of glycomimetic inhibitors of bacterial AB5 toxins, the design of anti-carbohydrate antibody ligands to develop anti-allergy drugs, and the development of electrosynthetic methods in carbohydrate chemistry.
The biological functions of sugars extend far beyond their classical roles as energy source and structural building blocks. The development of synthetic methods to prepare complex glycans, together with the advance of bioanalytical techniques, has unveiled unsuspected roles glycans play in a variety of physiological and pathological processes. To date, it is well known that glycosylation is one of the most common post-translational modification of proteins and that many biological functions involve the molecular recognition of a glycan by a protein receptor. Homeostasis, muscular integrity, inflammation, tumor metastasis, infection, and immune response are examples of biological processes involving protein-carbohydrate interactions. We are interested in the synthesis of carbohydrates and glycomimetics with applications in chemical biology and drug discovery with a special focus on glycans associated with neglected tropical diseases (NTD) and emerging infections.
October 1, 2022
Welcome Mehak Makhija! our new MS Medicinal Chemistry student. Mehak will work on designing glycomimetic inhibitors against bacterial toxins.
October 1, 2022
We welcome our new MS Chemistry students Alesia Bilbili and Jeetan Kaur. Alesia will start a brand new project on hyaluronidase inhibitors and Jeetan will continue pushing the boundaries of carbohydrate electrochemistry.
March 15, 2021
Jeetan Kaur has joined our group as undergraduate researcher. Jeetan is a 3rd year chemistry student. Welcome Jeetan!
July 31, 2020
Dhwani has successfully defended her MSc thesis titled: aGal antigen and rutinose glycosides as model compounds for the design of classical and conformational glycomimetics. Congratulations Dhwani!